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AssigneesOxford Nanopore Technologies PLC, Vib Vzw, Vrije Universiteit Brussel
InventorsHan Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
Estimating the term…
The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
-61. (canceled)
A pore comprising a CsgG pore and a modified CsgF peptide, wherein the modified CsgF peptide is bound to CsgG and forms a constriction in the pore.
The pore according to claim 1, wherein the CsgF peptide;
A CsgF peptide that is a modified CsgF peptide comprising a CsgG-binding region, and a region that forms a constriction in the pore.
A pore complex comprising:
Dependencies are inferred from the claim text.