Bicyclic peptide ligands specific for mt1-mmp
AssigneeBicycleTx Limited
InventorsLiuhong CHEN, Euan RICHARDS, Rachid LANI, Gemma MUDD, Catherine STACE, Daniel TEUFEL, Edward WALKER
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Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
Claims23
A peptide ligand specific for MT1-MMP comprising a polypeptide comprising at least three cysteine residues, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the cysteine residues of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold, characterised in that said molecular scaffold is 1,1,1″-(1,3,5-triazinane-1,3,5-triyl)triprop-2-en-1-one (TATA).
Dependencies are inferred from the claim text.