Peptidomimetic inhibitors of b-catenin/tcf protein-protein interaction

A compound having Formula I,

• wherein
• X is selected from O or N—Ra, wherein Ra is selected from hydrogen or C1-C3 alkyl;
• Z is selected from O or N—Ra, wherein Ra is selected from hydrogen or C1-C3 alkyl;
• R1 is absent or independently for each occurrence, selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 haloalkoxy, C1-C3 alkoxy, hydroxyl, amino, cyano, nitro, or isocyano;
• R2 is C1-C6 alkyl, C3-C10 cycloalkyl, a C2-C8 heterocycloalkyl, C5-C10 aryl, C2-C8 heteroaryl, alkylaryl, alkylheteroaryl, wherein R2 is optionally substituted with halogen, hydroxyl, carboxyl, amino, cyano, nitro, isocyano, alkyl, haloalkyl, haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R3 and R4 are independently halogen, hydroxyl, amino, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —R′CO2H, —R′CONH2, —R′CONHR″, —R′CONR″R′″, —R′CO2R″, —R′SO3H, —R′SO2NHCOR″, —R′CONHSO2R″, —R′CONHOH, —R′CONHCN, —R′SO2NHR″, C3-C6 cycloalkyl, C1-C8 heterocycloalkyl, C5-C10 aryl, C1-C8 heteroaryl, wherein R3 and R4 are optionally substituted with halogen, hydroxyl, amino, cyano, nitro, isocyano, carboxyl, hydroxyl, alkyl, alkoxy, alkenyl, haloalkyl, haloalkoxy, cyclopropyl, and wherein R′, R″, and R′″ are independently absent or is hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl;
• R5 is C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, a C1-C7 heterocycloalkyl, C5-C10 aryl, alkylaryl, C1-C8 heteroaryl, alkylheteroaryl, wherein R5 is optionally substituted with halogen, hydroxyl, amino, cyano, nitro, isocyano, carboxyl, hydroxyl, alkyl, alkoxy, alkenyl, haloalkyl, haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R6 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, or C1-C3 haloalkyl,
• n is 0, 1, 2, 3, or 4;
• wherein positions labeled 1, 2, and 3 indicate chiral positions;
• or
• a pharmaceutically acceptable salt or ester thereof.