Functionalized bile acids for therapeutic and material applications
AssigneeInternational Business Machines Corporation
InventorsJames L. Hedrick, Nathaniel H. Park
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Abstract
The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.
Claims20
A functionalized bile acid material comprising a chemical structure of Structure I:
- wherein R corresponds to a steroid backbone of a bile acid selected from the group consisting of cholic acid, chenodeoxycholic acid, lithocholic acid, deoxycholic acid, and glycocholic acid;
- and
- wherein X corresponds to an amine nucleophilic compound selected from the group consisting of diethanolamine, N,N,N′-trimethylethylenediamine, 1-methylpiperazine, 3,3′-iminobis(N,N-dimethylpropyl amine), 2-amino-2-methyl-1,3-propanediol, (4-(aminomethyl)phenyl)boronic acid, and 1-(3-aminopropyl)imidazole, and benzylamine.
A functionalized bile acid material comprising a chemical structure of Structure I:
- wherein R corresponds to a steroid backbone of a bile acid selected from the group consisting of cholic acid, chenodeoxycholic acid, lithocholic acid, deoxycholic acid, and glycocholic acid;
- and
- wherein X corresponds to an amine nucleophilic compound selected from the group consisting of ethanolamine, N,N-dimethylethylenediamine, 1-(3-aminopropyl)imidazole, benzylamine, and 2-amino-2-methylpropane-1,3-diol.
A functionalized bile acid material comprising a chemical structure of Structure I:
- wherein R corresponds to a steroid backbone of a bile acid selected from the group consisting of chenodeoxycholic acid, and glycocholic acid;
- and
- wherein X corresponds to an amine nucleophilic compound comprising a primary amine or a secondary amine coupled to the carbonyl group of Structure I.
Dependencies are inferred from the claim text.