Therapeutic compounds and compositions, and methods of use thereof

A compound of Formula (I)

• or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
• R1 is hydrogen, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, —(C0-C3alkyl)CN, —(C0-C3alkyl)ORa, —(C0-C3alkyl)Ra, —(C0-C3alkyl)SRa, —(C0-C3alkyl)NRaRb, —(C0-C3alkyl)OCF3, —(C0-C3alkyl)CF3, —(C0-C3alkyl)NO2, —(C0-C3alkyl)C(O)Ra, —(C0-C3alkyl)C(O)ORa, —(C0-C3alkyl)C(O)NRaRb, —(C0-C3alkyl)NRaC(O)Rb, —(C0-C3alkyl)S(O)1-2R, —(C0-C3alkyl)NRaS(O)1-2Rb, —(C0-C3alkyl)S(O)1-2NRaRb, —(C0-C3alkyl)(5-6-membered heteroaryl) or —(C0-C3alkyl)phenyl, wherein R1 is optionally substituted by one or more groups independently selected from the group consisting of halogen, C1-C3alkyl, oxo, —CF3, —(C0-C3alkyl)ORc and —(C0-C3alkyl)NRcRd;
• Ra is independently hydrogen, C1-C6alkyl, C3-C6cycloalkyl, 3-10 membered heterocyclyl, 5-6 membered heteroaryl, —C(O)Rc, —C(O)ORc, —C(O)NRcRd, —NRcC(O)Rd, —S(O)1-2Rc, —NRcS(O)1-2Rd or —S(O)1-2NRcRd, wherein any C3-C6cycloalkyl, 3-10 membered heterocyclyl, and 5-6 membered heteroaryl of Ra is optionally substituted with one or more groups Re;
• Rb is independently hydrogen or C1-C3alkyl, wherein said alkyl is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo;
• or
• Rc and Rd are independently selected from the group consisting of hydrogen, 3-6 membered heterocyclyl, C3-C6cycloalkyl, and C1-C3alkyl, wherein any 3-6 membered heterocyclyl, C3-C6cycloalkyl, and C1-C3alkyl of Rc and Rd is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo;
• or Rc and Rd are taken together with the atom to which they are attached to form a 3-6-membered heterocyclyl, optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, —CF3 and C1-C3alkyl;
• each Rc is independently selected from the group consisting of oxo, ORf, NRfRg, halogen, 3-10 membered heterocyclyl, C3-C6cycloalkyl, and C1-C6alkyl, wherein any C3-C6cycloalkyl and C1-C6alkyl of Rc is optionally substituted by one or more groups independently selected from the group consisting of ORf, NRfRg, halogen, 3-10 membered heterocyclyl, oxo, and cyano, and wherein any 3-10 membered heterocyclyl of Re is optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, cyano, —CF3, NRhRk, 3-6 membered heterocyclyl, and C1-C3alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, ORf, and NRhRk;
• Rf and Rg are each independently selected from the group consisting of hydrogen, C1-C6alkyl, 3-6 membered heterocyclyl, and C3-C6cycloalkyl, wherein any C1-C6alkyl, 3-6 membered heterocyclyl, and C3-C6cycloalkyl of Rf and Rg is optionally substituted by one or more Rm;
• each Rm is independently selected from the group consisting of halogen, cyano, oxo, C3-C6cycloalkyl, 3-6 membered heterocyclyl, hydroxy, and NRhRk, wherein any C3-C6cycloalkyl and 3-6 membered heterocyclyl of Rm is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, cyano, and C1-C3alkyl;
• Rh and Rk are each independently selected from the group consisting of hydrogen and C1-C6alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, cyano, 3-6 membered heterocyclyl, and oxo;
• or Rh and Rk are taken together with the atom to which they are attached to form a 3-6-membered heterocyclyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, cyano, oxo, —CF3 and C1-C3alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo;
• R2 is C1-C6alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6cycloalkyl, 3-6-membered heterocyclyl, (C3-C6cycloalkyl)C1-C6alkyl, (3-6-membered heterocyclyl)C1-C6alkyl, —C(O)(C3-C6cycloalkyl), or —C(O)(3-6-membered heterocyclyl), wherein R2 is substituted with one or more groups independently selected from the group consisting of hydroxy, C1-C6alkyl, C(O)C1-C6 alkyl and C(O)OC1-C6 alkyl;
• n is 0;
• R3 is hydrogen or NH2;
• R4 is hydrogen or CH3;
• and
• R5 is hydrogen or NH2.