High purity cantharidin manufacturing process and compositions
AssigneeSol-Gel Technologies Ltd.
InventorStephen CHERKEZ
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Abstract
Disclosed are topical compositions and methods of treatment of skin disorders selected from Molluscum contagiosum, verrucae and warts by topical administration to a subject in need thereof of a composition comprising between about 0.5%-1.0% w/w high-purity cantharidin. Also disclosed are processes for preparation of high-purity cantharidin.
Claims11
A process for the preparation of high-purity cantharidin comprising the following steps (i)-(iv):
- (i) conversion of cantharidin to a cantharidate salt selected from Na, K, Ca, Ba, Mg and Mn cantharidate;
- (ii) separation of the cantharidate salt of step (i) by filtration, washing with an organic solvent, crystallizing from a suitable solvent and drying;
- (iii) conversion of the cantharidate salt of step (ii) to cantharidin;
- and
- (iv) crystallization of the cantharidin of step (iii) from an organic solvent selected from ethyl acetate and acetone to afford high-purity cantharidin, wherein said high-purity cantharidin has an exo-endo ratio from 85:15 to 99:1, an assay of 97%-99% w/w and a cantharinic acid content equal or lower than 0.5% ww.
A stable topical composition for treatment of skin disorders selected from Molluscum contagiosum, verrucae and warts comprising between about 0.5%-1.0% w/w high purity cantharidin, wherein said high-purity cantharidin has an exo-endo ratio from 85:15 to 99:1, an assay of 97%-99% w/w and a cantharinic acid content equal or lower than 0.5% w/w, and a carrier suitable for topical administration.
Dependencies are inferred from the claim text.