Inhibitors of menin-mll interaction

A method for treating an autoimmune or heteroimmune disease or condition comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I):

• or a pharmaceutically acceptable salt thereof or pharmaceutical composition thereof, wherein:
• A is O, or N(R6a);
• Cy is
• wherein R7 is an optionally substituted group selected from a 4-7 membered heterocycloalkyl ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, phenyl, an 8-10 membered bicyclic aryl ring, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• one of X and Y is —NR3a—;
• and the other is —C(R3b)2—, —NR3b—, or —O—;
• R1 is an optionally substituted group selected from C1-6 alkyl, C3-7 cycloalkyl, phenyl, an 8-10 membered bicyclic aryl ring, a 4-7 membered heterocycloalkyl ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• R2 is H, C1-6 alkyl, C1-6 haloalkyl, halo, or CN;
• each R3a, and R3b is independently H or C1-6 alkyl;
• each R4 is independently H, halo, CN, OR, —N(R)2, —C(O)N(R)2,
• —NRC(O)R, —SO2R, —C(O)R, —CO2R, or an optionally substituted group selected from C1-6 alkyl, C3-7 cycloalkyl, a 4-7 membered heterocycloalkyl ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, phenyl, an 8-10 membered bicyclic aryl ring, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each R is independently H, or an optionally substituted group selected from C1-6 aliphatic, phenyl, an 8-10 membered bicyclic aryl ring, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or:
• two R groups on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered saturated, partially unsaturated, or heteroaryl ring having 0-3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, or sulfur;
• R6a is H or and C1-6 alkyl;
• and
• n is 1, 2, 3, or 4.