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US 2022/0024935 A1Published application
Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau
AssigneeNantNeuro, LLC
InventorsVarghese John, Oleksandr Buzko, Dale Bredesen, Patricia Spilman, Barbara Jagodzinska
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Abstract
Pharmaceutical compounds, compositions, methods, and uses therefor are presented using selected triazolopyridines and triazolopyrimidines to inhibit or reduce phosphorylation of tau proteins or that act as antagonists of corticotropin-releasing factor. Viewed from another perspective, compounds, compositions, and methods are presented for treating or preventing symptoms of Alzheimer's disease by inhibiting or reducing the phosphorylation of tau proteins.
Claims20
A method of inhibiting tau phosphorylation in a patient in need thereof, comprising:
- administering to the patient a pharmaceutical composition comprising a compound having a structure according to Formula I
- wherein:
- X is N or CH;
- R1 is selected from a group consisting of
- R3 is selected from a group consisting of
- and
- R2 is hydrogen, deuterium, CH3, CF3, CHF2, or CH2F.
4 more elements
Dependencies are inferred from the claim text.