Mitragynine analogs and uses thereof

A compound of Formula (I′):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• each of R10, R11, R12, and R13 is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, and —SRA;
• wherein:
• is a single bond or double bond;
• each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, —SRA, —SeRA, —C(═O)RC, —C(═O)ORA, —C(═O)N(RB)2, —OC(═O)RC, —OC(═O)N(RB)2, —NRBC(═O)RC, —NRBC(═O)ORA, —NRBC(═O)N(RB)2, S(═O)RC, —SO2RC, —NRBSO2RC, and —SO2N(RB)2;
• R5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —C(═O)RC, —C(═O)ORA, —C(═O)N(RB)2, S(═O)RC, —SO2RC, —SO2N(RB)2, or a nitrogen protecting group;
• R6 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, —SRA, —C(═O)RC, —C(═O)ORA, —C(═O)N(RB)2, —OC(═O)RC, —OC(═O)N(RB)2, —NRBC(═O)RC, —NRBC(═O)ORA, —NRBC(═O)N(RB)2, S(═O)RC, —SO2RC, —NRBSO2RC, or —SO2N(RB)2;
• or R5 and R6 are absent and is a double bond;
• R7 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORA, —OC(═O)RC, —C(═O)RC, —C(═O)ORA, —OC(═O)N(RB)2, —C(═O)N(RB)2, S(═O)RC, —SO2RC, —SO2N(RB)2, or an oxygen protecting group;
• each of R10, R11, R12, and R13 is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, and —SRA;
• or R12 and R13 are taken together to form an optionally substituted alkenyl moiety;
• R14 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group;
• each of R5 and R16 is independently selected from the group consisting of hydrogen, halogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —CN, —N3, —ORA, —N(RB)2, and —SRA;
• each of R17 and R18 is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, and —SRA;
• or R17 and R18 are taken together to form
• each instance of RA is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, an oxygen protecting group when attached to oxygen, or a sulfur protecting group when attached to sulfur, or a selenium protecting group when attached to selenium;
• each instance of RB is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or a nitrogen protecting group, or two RB groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;
• and
• each instance of RC is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl