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US 2022/0024908 A1Published application
Preparation method for deuterated macrocyclic compound
AssigneeShenzhen TargetRx, Inc.
InventorsYihan Wang, Huanyin Li
Life of this patent
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Abstract
Provided are a compound as represented by formula (D) and a preparation method therefor, where X2 is a halogen, Pg is selected from H and an amino protecting group, such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl or ethoxycarbonyl. Also provided are a synthesized intermediate compound of the formula (D) compound and a preparation method for the intermediate compound.
Claims15
-18. (canceled)
A method for preparing a compound of formula (A), comprising the step of:
- reacting a compound of formula (F) with a compound of formula (E-a) to form a compound of formula (D-a):
- wherein X2 is halogen, and Pg1 is a hydroxy-protecting group such as Ms, Ns, Ts, or Tf;
- alternatively, reacting a compound of formula (G) with a compound of formula (E-b) to form a compound of formula D-b):
- wherein X2 is halogen, and Pg2 is an amino-protecting group such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl, or ethoxycarbonyl.
1 more element
A compound of formula (D):
- wherein X2 is halogen, and Pg is selected from H and an amino-protecting group such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl, or ethoxycarbonyl.
A compound of formula (C),
- wherein X2 is halogen, and Pg2 is an amino-protecting group such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl, or ethoxycarbonyl.
Dependencies are inferred from the claim text.