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US 2022/0024904 A1Published application
Reagent for bioconjugation via irreversible rebridging of disulfide linkages
OwnerBrian Zeglis, Guillaume Dewaele-Le Roi +2inventors
InventorsBrian Zeglis, Guillaume Dewaele-Le Roi, Eric W. Price, Elaheh Khozeimeh Sarbisheh
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Abstract
A label that permits rebridging of disulfide linkages in antibodies or proteins. The label has a general formula given by wherein R1 is methyl, ethyl or propyl and R2 is a metal chelator, a fluorophore or a click-chemistry synthon.
Claims20
A composition of matter consisting of:
- wherein R1 is methyl, ethyl or propyl and R2 is a fluorescent label, a metal chelator or a click-chemistry synthon.
A method for labeling a substrate, the method comprises steps of:
- exposing a label to a substrate that comprises two cysteine residues, wherein the label comprises:
- wherein R1 is methyl, ethyl or propyl and R2 is a fluorescent label, a metal chelator or a click-chemistry synthon;
- permitting the label to covalently bind to the two cysteine residues of the substrate, thereby labeling the substrate.
A composition of ma ter consisting of:
- wherein R1 is methyl, ethyl or propyl and R2 is
Dependencies are inferred from the claim text.