Method for producing kakeromycin and derivatives thereof
AssigneesOp Bio Factory Co., Ltd., Seed Research Institute Co., Ltd.
InventorsTeruhiko ISHIKAWA, Morita IWAMI
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Abstract
Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
Claims13
A compound represented by the formula (3):
- wherein
- when n is 0, R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and
- when n is 1, R is (1) a group represented by formula (A):
- wherein R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, (2) an optionally substituted C1-20 alkyl group, (3) an optionally substituted C5-20 aryl group, or (4) an optionally substituted C7-20 aralkyl group, or a salt thereof.
Dependencies are inferred from the claim text.