Method for preparing contrast agent iomeprol
AssigneeUK Chemipharm Co., Ltd
InventorsYoung-Seon OH, Jung-Jin KIM, Young-Keun LEE, Young-Nam CHA, Gi-Bum OH
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Abstract
The present invention relates to a method for preparing an X-ray contrast agent iomeprol and, more specifically, to a method for preparing iomeprol by adding an inorganic base, an inorganic chloride, a solvent, etc. to 5-(2-hydroxyacetamido)-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (1b) to cause N-methylation reaction, thereby enabling easy separation and removal of inorganic salts generated during the reaction, without treatment with an ion exchange resin, while reducing the conventional production time, and minimization of the amount of reaction impurities.
Claims11
Method for preparing iomeprol, comprising a step of performing N-methylation reaction by adding an N-methylating agent, an inorganic base, an inorganic chloride and a solvent to 5-(2-hydroxyacetamido)-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide.
Dependencies are inferred from the claim text.