Method for preparing 2-ethyl-4-fluoro-1-nitrobenzene
AssigneeAccela Chembio Co., Ltd.
InventorsYang LIU, Duoqing XUE, Yong WU, Lihuang CHEN, Lianhua ZHAI
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Abstract
The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.
Claims20
A method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, comprising,
- (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone;
- (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone obtained in step (1) with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene;
- (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene obtained in step (2), to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene;
- and
- (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene obtained in step (3) with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene;
- wherein the reaction route of the method is shown in Formula 1:
Dependencies are inferred from the claim text.