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US 2022/0024849 A1Published application
Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
AssigneeChirogate International Inc.
InventorsSHIH-YI WEI, MING-KUN HSU, TZYH-MANN WEI
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Abstract
Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.
Claims9
A process for preparing latanoprostene bunod comprising reacting latanoprost acid with 1,4-butanediol dinitrate.
A compound of Formula LB-3Si
- wherein Ra, Rb and Rc are each independently C1-8 alkyl, phenyl, benzyl, a substituted phenyl, or a substituted benzyl.
A compound of Formula LB-dimer
Dependencies are inferred from the claim text.