Optimizing neuromodulation stimulation parameters using blood parameter sensing

A system comprising:

• an implantable neurostimulator including:
• a controller configured to:
• deliver neural stimulation using a pulse generator and one or more electrodes based on a first set of stimulation parameters to a nerve or artery/nerve plexus;
• monitor a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus, wherein monitoring the response to the neural stimulation includes determining whether the neural stimulation has a physiological effect;
• modify the first set of stimulation parameters based on the monitored response to create a second set of stimulation parameters;
• and
• deliver the neural stimulation using the pulse generator and the one or more electrodes based on the second set of the stimulation parameters.

A method comprising:

• delivering, by a computing system, neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters;
• monitoring, by the computing system, a response to the neural stimulation that includes monitoring whether the neural stimulation has a physiological effect or changes to blood-based parameters;
• modifying, by the computing system, the first set of stimulation parameters based on the physiological effect or blood-based parameters to create a second set of stimulation parameters;
• and
• delivering, by the computing system, the neural stimulation based on the second set of the stimulation parameters.