Biodegradable Polymer Compositions
AssigneeCorMatrix Cardiovascular, Inc.
InventorRobert G. Matheny
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Abstract
The invention is a biodegradable polymer composition comprising a particulate biodegradable polymer, particulate extracellular matrix (ECM) derived from a mammalian tissue source, a therapeutic component that abates growth of bacteria and a liquid medium. The biodegradable polymer can change quality upon contact with a physiological parameter, such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The polymer composition is adapted to induce regeneration of tissue in vivo.
Claims6
A composition for regenerating biological tissue, comprising:
- a fluidized biodegradable polymer composition comprising a particulate biodegradable polymer, particulate extracellular matrix (ECM), a therapeutic component and a liquid medium,
- said particulate biodegradable polymer comprising polylactide (PLA),
- said therapeutic component comprising a therapeutic agent that abates growth of bacteria,
- said liquid medium selected from the group consisting of H2O and saline,
- said particulate ECM derived from a mammalian tissue source selected from the group consisting of small intestine tissue, placental tissue and dermal tissue,
- said particulate ECM comprising a concentration in the range of 30 mg/ml to 50 mg/ml of said liquid medium,
- said fluidized biodegradable polymer composition adapted to induce regeneration of new biological tissue when disposed proximate damaged biological tissue.
A composition for regenerating biological tissue, comprising:
- a fluidized biodegradable polymer composition comprising a biodegradable polymer, particulate extracellular matrix (ECM), a therapeutic component and a liquid medium,
- said biodegradable polymer comprising polyvinyl alcohol,
- said therapeutic component comprising a therapeutic agent that abates growth of bacteria,
- said liquid medium selected from the group consisting of H2O and saline,
- said particulate ECM derived from a mammalian tissue source selected from the group consisting of small intestine tissue, placental tissue and dermal tissue,
- said particulate ECM comprising a concentration in the range of 30 mg/mi to 50 mg/ml of said liquid medium,
- said fluidized biodegradable polymer composition adapted to induce regeneration of new biological tissue when disposed proximate damaged biological tissue.
Dependencies are inferred from the claim text.