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US 2022/0023503 A9Published application
Extracellular Matrix Tissue Prostheses
AssigneeAziyo Med, LLC
InventorRobert G Matheny
Life of this patent
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Abstract
Tissue prostheses having a base structure and a physiological sensor system. The tissue prostheses are adapted and configured to induce remodeling of damaged tissue and regeneration of new tissue and concurrently detect and monitor physiological characteristics when implanted in the subject.
Claims16
A tissue prosthesis, comprising:
- a base structure and a physiological sensor system, said physiological sensor system being joined to said base structure,
- said base structure comprising an extracellular matrix (ECM) composition comprising acellular ECM from a mammalian tissue source, said base structure, when disposed proximate damaged biological tissue, being adapted to induce modulated healing of said damaged tissue, said modulated healing comprising reducing an inflammatory phase of said damaged tissue and inducing host tissue proliferation, bioremodeling and, thereby, neovascularization of said damaged tissue, and regeneration of new tissue and tissue structures,
- said base structure and physiological sensor system being jointly adapted to concurrently induce said modulated healing and detect at least one physiological parameter of said subject, when disposed proximate said damaged biological tissue of said subject.
A tissue prosthesis, comprising:
- a base structure and a physiological sensor system, said physiological sensor system being joined to said base structure,
- said base structure comprising a polymeric composition comprising at least one biodegradable polymer,
- said physiological sensor system being adapted to detect at least one physiological parameter of said subject in vivo.
Dependencies are inferred from the claim text.