Autologous Bone Graft Substitute Composition Comprising Bioceramic Particles of Different Geometry

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating of bone defect, wherein the composition comprises:

• i) autologous blood;
• (ii) an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, analogs thereof or heterodimers thereof, and combinations thereof, in a range of from 2 to 1000 μg per mL of autologous blood;
• and
• (iii) hydroxyapatite, tri-calcium phosphate, or a mixture thereof as a compression resistant matrix, the compression resistant matrix comprises particles having a particle size in a range of from above 74 to 8000 μm,
• wherein the autologous blood forms the autologous blood coagulum comprising a fibrin-meshwork reinforced with the compression resistant matrix, the coagulum gel containing the osteogenic bone morphogenetic protein, whereby the coagulum gel and the compression resistant matrix provide a sustained multiphasic release of the osteogenic bone morphogenetic protein.