Pneumococcal dosing regimen

A method of eliciting an immunoprotective antibody response to a capsular polysaccharide of Streptococcus pneumoniae in an older subject, comprising administering to a older subject an immunogenic amount of an initial pneumococcal polysaccharide conjugate vaccine, wherein the subject has previously received a pneumococcal unconjugated polysaccharide vaccine, and wherein the prior administration of pneumococcal vaccine was administered at an interval selected from the group consisting of at least one year, at least two years and at least five years prior to administration of the initial pneumococcal polysaccharide conjugate vaccine administration.

A method of eliciting an immunoprotective antibody response to a capsular polysaccharide of Streptococcus pneumoniae in an older subject, comprising administering to a naive older subject an immunogenic amount of an initial pneumococcal polysaccharide conjugate vaccine;

• and administering a second dose comprising an immunogenic amount of an unconjugated pneumococcal polysaccharide vaccine, wherein the second dose is administered at a time selected from the group consisting of about two weeks, about one month, about six weeks, about two months, about three months, about six months, about nine months, about twelve months, about fifteen months, about eighteen months, about twenty-one months and about twenty four months following the initial vaccine administration.

A method of immunizing an older subject against pneumococcal pneumonia, comprising administering to a naive older subject an immunogenic amount of an initial pneumococcal polysaccharide conjugate vaccine.

A method of immunizing against a Streptococcus pneumoniae-caused disease in an older subject, comprising administering to an older subject an immunogenic amount of a pneumococcal polysaccharide conjugate vaccine by a method selected from intramuscular, intradermal, subcutaneous, or intranasal delivery.