Combination product for use in tumor vaccination
AssigneeDcprime B.V.
InventorsErik Hans MANTING, Satwinder Kaur SINGH, Adriana Maria KRUISBEEK, Vinod SOMMANDAS
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AssigneeDcprime B.V.
InventorsErik Hans MANTING, Satwinder Kaur SINGH, Adriana Maria KRUISBEEK, Vinod SOMMANDAS
Estimating the term…
The present invention relates to a combination product for use in eliciting an immune response against a tumor in a subject, said product comprising: —an immunogenic composition comprising a non-human antigenic polypeptide as an immunogen, or comprising a nucleic acid encoding said immunogen, and optionally one or more pharmaceutically-acceptable carriers, adjuvants, excipients and/or diluents; and —said non-human antigenic polypeptide, or a nucleic acid encoding said polypeptide; wherein said polypeptide or said nucleic acid is prepared for intratumoral delivery. The invention also provides fusion proteins and protein-protein conjugates that can be used in the medical methods described herein.
An immunogenic composition that elicits an immune response against a tumor in a subject comprising a first part comprising a non-tumor antigen or a nucleic acid sequence encoding the non-tumor antigen, and optionally one or more pharmaceutically-acceptable carriers, adjuvants, excipients and/or diluents;
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A non-tumor antigen, or a nucleic acid sequence encoding said non-tumor antigen, for use in eliciting or directing an immune response against a tumor in a subject;
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A cell having a dendritic phenotype comprising a non-tumor antigen, or a nucleic acid sequence encoding said non-tumor antigen, for use in marking a tumor as a target for an immune response in a subject, wherein said cell having a dendritic phenotype is for intratumoral administration.
A fusion protein or a protein-protein conjugate comprising a first protein linked to a second protein, wherein said first protein comprises a diphtheria toxin or a receptor-binding domain of diphtheria toxin, and said second protein comprises a non-tumor antigen polypeptide.
A method for eliciting an immune response against a subject suffering from a tumor, comprising the steps of:
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Dependencies are inferred from the claim text.