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US 2022/0023394 A1Published application
Methods for desensitization of uricase
OwnerJohn Kenneth Botsoninventor
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Abstract
Disclosed are methods for treating gouty arthropathy in a subject that is allergic to a uricase. In some aspect, disclosed herein are methods for desensitizing a subject allergic to a uricase.
Claims23
A method for desensitizing a subject allergic to a uricase, said method comprising
- 1) administering solution 1 to the subject at the rate of about 2 ml/hour with the duration of about 15 min;
- 2) administering solution 1 to the subject at the rate of about 5 ml/hour with the duration of about 15 min;
- 3) administering solution 1 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 4) administering solution 1 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 5) administering solution 2 to the subject at the rate of about 5 ml/hour with the duration of about 15 min;
- 6) administering solution 2 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 7) administering solution 2 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 8) administering solution 2 to the subject at the rate of about 40 ml/hour with the duration of about 15 min;
- 9) administering solution 3 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 10) administering solution 3 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 11) administering solution 3 to the subject at the rate of about 40 ml/hour with the duration of about 15 min;
- and
- 12) administering solution 3 to the subject at the rate of about 80 ml/hour with the duration of about 174.375 min.
10 more elements
(canceled)
(canceled)
A method for treating gouty arthropathy in a subject, said method comprising
- 1) administering solution 1 to the subject at the rate of about 2 ml/hour with the duration of about 15 min;
- 2) administering solution 1 to the subject at the rate of about 5 ml/hour with the duration of about 15 min;
- 3) administering solution 1 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 4) administering solution 1 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 5) administering solution 2 to the subject at the rate of about 5 ml/hour with the duration of about 15 min;
- 6) administering solution 2 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 7) administering solution 2 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 8) administering solution 2 to the subject at the rate of about 40 ml/hour with the duration of about 15 min;
- 9) administering solution 3 to the subject at the rate of about 10 ml/hour with the duration of about 15 min;
- 10) administering solution 3 to the subject at the rate of about 20 ml/hour with the duration of about 15 min;
- 11) administering solution 3 to the subject at the rate of about 40 ml/hour with the duration of about 15 min;
- and
- 12) administering solution 3 to the subject at the rate of about 80 ml/hour with the duration of about 174.375 min.
10 more elements
(canceled)
Dependencies are inferred from the claim text.