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AssigneeOxford University Innovation Limited
InventorsJagdeep Nanchahal, Ana Isabel Espirito Santo, Geoffrey Lee, James Chan, Nicole Horwood, Marc Feldmann
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The subject invention provides a method of preventing or treating a condition associated with a defect in, or damage to, an organ in a subject with, or at risk for, such defect or damage to such organ which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent or treat such condition. The subject invention also provides a method of improving regeneration of blood in a subject comprising administering a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, effective to improve regeneration of blood.
A method of preventing or treating a condition associated with a defect in or damage to an organ or a tissue of such organ in a subject with, or at risk for, such defect or damage to such organ or tissue which comprises administering to the subject a prophylactically or therapeutically effective amount of a fully reduced (all thiol) form of HMGB1 or of a biologically active truncated form of HMGB1, so as to prevent or treat such condition, wherein the subject is, or is anticipated to be, in need of prevention or treatment of the condition in the future, and wherein the organ or tissue relies on repair by stem or parenchymal cells that express the cell surface receptor CXCR4.
2-6. (canceled)
A method of improving regeneration of blood in a subject comprising administering a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or of a biologically active truncated form of HMGB1 so as to improve regeneration of blood, wherein the subject is in need of improved regeneration of blood, or is anticipated to be in need of improved regeneration of blood in the future.
11-13. (canceled)
(canceled)
24-26. (canceled)
Dependencies are inferred from the claim text.