Identification of gut bacteria that promote an anti-tumor response to immunotherapy
AssigneePresident and Fellows of Flarvard College
InventorsFrancesca S. Gazzaniga, Dennis Kasper, Joon Seok Park, Arlene H. Sharpe
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Abstract
In certain aspects, provided herein are methods and compositions for treating or preventing cancer in a subject by conjointly administering to a subject a composition comprising a bacterium (e.g., a bacterium species or strain disclosed herein) and an immunotherapeutic agent.
Claims60
A method of treating or preventing cancer in a subject, the method comprising conjointly administering to a subject a composition comprising a Clostridia bacterium and an immunotherapeutic agent.
A method of treating or preventing cancer in a subject, the method comprising conjointly administering to a subject a composition comprising at least one bacteria species selected from Clostridium innocuum, Erysipelatoclostridium ramosum, Coprobacillus catenaformis, Bacteroides dorei, Flavonifractor plautii, and Blautia hydrogenotrophica and an immunotherapeutic agent.
A method of treating or preventing cancer in a subject, the method comprising conjointly administering to a subject a composition comprising Clostridium innocuum, Erysipelatoclostridium ramosum, Coprobacillus catenaformis, Bacteroides dorei, Flavonifractor plautii, and Blautia hydrogenotrophica, and an immunotherapeutic agent.
A method of treating or preventing cancer in a subject, the method comprising conjointly administering to a subject a composition comprising Clostridium innocuum, Erysipelatoclostridium ramosum, Coprobacillus catenaformis, and Bacteroides dorei, and an immunotherapeutic agent.
Dependencies are inferred from the claim text.