Combination therapies of microorganisms and immune modulators for use in treating cancer
AssigneeSynlogic Operating Company, Inc.
InventorsJose M. Lora, Anna Sokolovska
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Abstract
Combination therapies comprising a microorganism and an immune modulator, and methods of modulating and treating cancers are disclosed.
Claims55
A pharmaceutical composition comprising an isolated bacterium, at least one immune modulator, and a pharmaceutically acceptable carrier, wherein the bacterium is a wild-type bacterium or a bacterial chassis.
The composition of any one of the previous claims, wherein the at least one immune modulator comprises at least one immune initiator and at least one immune sustainer.
The composition of any one of the previous claims, wherein the at least one immune modulator is not produced by the bacterium.
The composition of any one of the previous claims, wherein the bacterium is a wild-type E. coli Nissle bacterium.
The composition of any one of the previous claims, wherein the composition is formulated for intratumoral administration.
A syringe comprising the composition of any one of the previous claims.
A kit comprising:
- i) a first composition comprising an isolated bacterium, wherein the bacterium is a wild-type bacterium or a bacterial chassis,
- ii) a second composition comprising an immune modulator, and
- iii) instructions for use thereof.
A method of treating cancer in a subject, the method comprising
- administering a bacterium to the subject, wherein the bacterium is a wild-type bacterium or a bacterial chassis;
- and
- administering at least one immune modulator to the subject,
- thereby treating cancer in the subject.
A method of inducing and sustaining an immune response in a subject, the method comprising
- administering a bacterium to the subject, wherein the bacterium is a wild-type bacterium or a bacterial chassis;
- and
- administering at least one immune modulator to the subject,
- thereby inducing and sustaining the immune response in the subject.
A method of activating antigen presenting cells in a tumor in a subject, the method comprising administering a bacterium to the subject, wherein the bacterium is a bacterial chassis or a bacterium producing a STING agonist, wherein the bacterium undergoes phagocytosis after administration in the subject, thereby activating antigen presenting cells in the tumor in the subject.
Dependencies are inferred from the claim text.