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AssigneesRiken, Keio University
InventorsYoshihiro Ito, Kenya Honda, Masayuki Amagai, Eiryo Kawakami
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In the present invention, the influence by flora of the skin on dermatitis is examined by analyzing Tmem79-knockout model mice, and a bacterium having a suppressive effect on dermatitis is identified, and the present invention relates to a pharmaceutical composition derived from such a bacterium, containing as active components one or more substances selected from: (a) a bacterial cell of an ampicillin-sensitive bacterium, or a constituent component of the bacterium; (b) a culture supernatant of an ampicillin-sensitive bacterium, or a purified product from the culture supernatant; (c) an extract of an ampicillin-sensitive bacterium; and (d) a metabolite of an ampicillin-sensitive bacterium.
A pharmaceutical composition, comprising as active components one or more substances selected from the following (a) to (d):
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A method for treatment of skin disease, comprising administering to a patient one or more substances selected from a bacterial cell of a bacterium sensitive to ampicillin, a constituent component of the bacterium, a culture supernatant of the bacterium, a purified product from the culture supernatant, an extract of the bacterium, and a metabolite of the bacterium.
A bacterium strain belonging to the species S. cohnii specified by Accession number NITE BP-02848, NITE BP-02850, NITE BP-02851, NITE BP-02852, or NITE BP-02853.
Dependencies are inferred from the claim text.