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AssigneeUniversiteit Antwerpen
InventorsKoen Augustyns, Jurgen Joossens, Pieter Van Der Veken, Paul Cos, Cedric Joossen, Benedicte Yvonne De Winter, Hannah Ceuleers, Hanne Van Spaendonk
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The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.
1-15. (canceled)
A method for treating visceral pain and/or visceral hypersensitivity in a protease-activated receptor (PAR)-related gastrointestinal disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a bis(acetamidophenyl) guanidinophenylethylphosphonate compound.
A method for treating visceral pain and/or visceral hypersensitivity in a protease-activated receptor (PAR)-related gastrointestinal disorder in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition, the pharmaceutical composition comprising:
Dependencies are inferred from the claim text.