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AssigneeResearch Cooperation Foundation of Yeungnam University
InventorsJae-Ryong KIM, Eok-Cheon KIM, Kyong-Jin JUNG, Bum-Ho BIN, You Lim SON
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The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising homoharringtonine as an active ingredient, and it was confirmed that the composition comprising homoharringtonine as an active ingredient exhibits a senolytics effect of selectively killing aging-induced fibroblasts and renal tubular cells, whereas aging-induced vascular endothelial cells and epithelial melanocytes and retinal pigmented epithelial cells, and exhibits a senomorphics effect of restoring the function and morphology of cells, and thus the homoharringtonine acts differently depending on the type of cells to effectively prevent or treat senile eye disease, tissue fibrosis disease, atherosclerosis, osteoarthritis, degenerative brain disease, chronic skin damage, obesity and diabetes caused by cellular aging and can be provided as a composition for whitening skin and life extension.
A composition having a senolytic activity comprising homoharringtonine as an active ingredient.
A composition having a senomorphic activity comprising homoharringtonine as an active ingredient.
A method for preventing or treating a cellular senescence-associated disease comprising administering a pharmaceutical composition comprising homoharringtonine as an active ingredient to a subject in need of the preventing or treating the cellular senescence-associated disease.
A method for whitening skin comprising administering a cosmetic composition comprising homoharringtonine as an active ingredient to a subject in need of the whitening skin.
A method for improving aging or extending life comprising administering a pharmaceutical composition comprising homoharringtonine as an active ingredient to a subject in need of the improving aging or extending life.
Dependencies are inferred from the claim text.