METHODS OF TREATING AUTOIMMUNE DISEASES WITH SMALL MOLECULE NF-kB INHIBITORS

A method for treating autoimmune diseases in a subject, comprising administering to the subject an effective amount of a compound having the structure of formula (I):

• wherein:
• A, B, C, and D are independently selected from the group consisting of carbon and nitrogen;
• X, Y, and Z are independently selected from the group consisting of oxygen, sulfur, and NRa;
• R1, R2, R3, and R4 are independently selected from the group consisting of no atom, hydrogen, halogen, C1-9 alkyl, C2-9 alkenyl, C2-9 alkynyl, aryl, heterocyclic, —OH, —ORa, —ORaORb, —ORaORbORc, —ORa(C═O)Rb—O(C═O)Ra, —O(C═O)ORa, —O(C═O)NRaRb, cyano, nitro, —CF3, —CHF2, —CH2F, —CHO, —COOH, —CORa, —COORa, —CONRaRb, —CONHCONRaRb, —NRaRb, —NHCORa, —NRbCORa, —CSOH, —CSRa, —CSORa, —CSNRaRb, —CSNHCSNRaRb, —SH, —SRa, —S(C═O)Ra, —S(C═O)ORa, and —S(C═O)NRaRb;
• R5 is selected from the group consisting of hydrogen, C1-9 alkyl, C2-9 alkenyl, C2-9 alkynyl, aryl, heterocyclic, —RaCO, —RaNHCO, and —RaOCO;
• and
• R6, Ra, Rb, and Rc are independently selected from the group consisting of hydrogen, hydroxyl, amine, C1-9 alkyl, C2-9 alkenyl, C2-9 alkynyl, aryl, and heterocyclic,
• or a crystalline form, hydrate, or pharmaceutically acceptable salt thereof.