Analogs of pridopidine, their preparation and use

A method of treating, slowing the progression, lessening the decline, delaying onset of symptoms or slowing the progression of symptoms of a neurodegenerative or neurodevelopmental disease or disorder in a subject;

• wherein the method comprises administering a composition comprising pridopidine or a pharmaceutically acceptable salt thereof and at least one of Compounds 1-8 or pharmaceutically acceptable salt thereof:
• wherein the neurodegenerative disease or disorder is selected from the group consisting from Huntington Disease, prodromal/premanifest Huntington disease, Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease, Parkinson's Disease associated with glucocerebrosidase (GBA) deficiency, dystonia, cognitive disorder, dyskinesia, mild cognitive impairment (MCI), Alzheimer's Disease, age related memory loss, depression and anxiety, bacterial infections-induced depression, optic neuropathies including glaucoma, age-related macular degeneration (AMD), Leber's Hereditary Optic Neuropathy (LHON) and retinitis pigmentosa, mitochondrial disease or dysfunction, Wolfram disease and a viral infection;
• and wherein the neurodevelopmental disease or disorder is Rett syndrome and Fragile X Syndrome.