Carbonic anhydrase targeting agents and methods of using same

A carbonic anhydrase targeting agent represented by formula (I), or a salt thereof:

• wherein:
• CAB is a carbonic anhydrase binding moiety comprising a sulfonamide and an aliphatic, aromatic or heteroaromatic moiety;
• Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C18 alkyl, alkenyl, alkynyl, alkoxy, or thioalkyl group;
• or Q is absent;
• L1, L2, and L3 are, independently for each occurrence, a bond or a linker moiety;
• W is a naphtho-condensed ring;
• X is S;
• Y1 and Y2 are independently hydrogen or a C1-C20 aliphatic group, each of which is optionally substituted with L3-M;
• M, independently for each occurrence, is hydrogen or a chemical modifying moiety selected from the group consisting of alcohol, sulfonic acid, sulfonate, polysulfonate, cysteic acid, sulfonamide, sulfoxide, sulfone, carboxylate, ketone, phosphonate, phosphate;
• iminodiacetate, ethylenediamine tetra-acetic acid, diethylenetriamine pentaacetic acid, tetra-azacyclododecane tetra-acetic acid, an amino acid or polyamino acid, oligo- or polyethylene glycol, amine, quaternary ammonium ion, a sugar, glucosamine, galactosamine, mannosamine, polyethylene glycol (PEG), alkoxy polyethylene glycol, a branched polypropylene glycol, polypropylene glycol, a graft copolymer of poly-lysine and methoxypolyethyleneglycol, a peptide, a lipid, a fatty acid, palmitate, phospholipid, a phospholipid-PEG conjugate, a carbohydrate, an iron oxide nanoparticle, naphthylalanine, phenylalanine, 3,3-diphenylpropylamine, taurine, a phosphonate, a phosphate, a carboxylate, and a polycarboxylate.