Donepezil eutectic mixture and use thereof
AssigneesIndustry-Academic Cooperation Foundation, Yonsei University, Ebabio Inc.
InventorsSung Joo HWANG, Sang Min HYUN, Sharif Md ABUZAR, Soo Hun LEE, Eun Seok LEE, Bo Kyung SUN
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Abstract
The present invention relates to a donepezil eutectic mixture and a use thereof. A eutectic mixture of the present invention allows increased solubility and skin permeability of donepezil, and a pharmaceutical composition including the same does not generate donepezil crystals and maintains amorphous form even when stored under various conditions, thereby being applicable to various formulations while also having excellent stability and efficacy.
Claims18
A donepezil eutectic mixture comprising donepezil and coformer, wherein the coformer is dicarboxylic acid or vanilin.
A method of manufacturing a donepezil eutectic mixture, the method comprising mixing donepezil and coformer, wherein the coformer is dicarboxylic acid or vanilin.
Dependencies are inferred from the claim text.