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AssigneeResearch Cooperation Foundation of Yeungnam University
InventorsJae-Ryong KIM, Eok-Cheon KIM, Kyong-Jin JUNG, You Lim SON
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The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising zotarolimus as an active ingredient, and in more detail, it was confirmed that zotarolimus exhibits a senomorphics effect of restoring the function and morphology of fibroblasts, umbilical vascular endothelial cells, renal tubular cells and retinal pigmented epithelial cells, in which senescence is induced and exhibits an effect of improving tissue fibrosis induced by cellular aging through the senomorphics effect and thus the composition comprising zotarolimus as an active ingredient can be provided as a composition for treating cellular senescence-associated diseases.
A composition having a senomorphic activity comprising zotarolimus as an active ingredient.
A method for preventing or treating a cellular senescence-associated disease comprising administering a pharmaceutical composition comprising zotarolimus as an active ingredient to a subject in need of the preventing or treating the cellular senescence-associated disease.
A method for improving aging or extending life comprising administering a pharmaceutical composition comprising zotarolimus as an active ingredient to a subject in need of the improving aging or extending life.
Dependencies are inferred from the claim text.