Topical compositions and methods for treating inflammatory skin diseases
AssigneeAzora Therapeutics, Inc.
InventorsMatthew Davidson, Julie Saiki, Johan Andreasson
Life of this patent
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Abstract
Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.
Claims22
A method for treating an inflammatory disease, comprising:
- administering to skin or mucosal tissue of a subject a composition comprising a therapeutically effective amount of synthetic indirubin, thereby treating an inflammatory skin or mucosal disease in the subject,
- wherein the composition is free of crystalline indirubin.
A method for treating nail psoriasis, comprising:
- administering to a subject a composition comprising a therapeutically effective amount of synthetic indirubin, thereby treating the nail psoriasis in the subject,
- wherein the composition is free of crystalline indirubin and is not an extract of Indigo naturalis.
A method for treating pyoderma gangrenosum, comprising:
- administering to a subject a composition comprising a therapeutically effective amount of synthetic indirubin, thereby treating the pyoderma gangrenosum in the subject,
- wherein the composition is free of crystalline indirubin.
A method for treating palmoplantar pustulosis, comprising:
- administering to a subject a composition comprising a therapeutically effective amount of synthetic indirubin, thereby treating the palmoplantar pustulosis in the subject,
- wherein the composition is free of crystalline indirubin.
A method for treating proctitis, comprising:
- administering to a subject a composition comprising a therapeutically effective amount of synthetic indirubin, thereby treating proctitis in the subject,
- wherein the composition is free of crystalline indirubin.
A topical composition, comprising:
- an oleaginous compound that is an oily liquid at between about 23-25° C., a wax, an aprotic solvent, and between about 0.001-0.3 weight percent indirubin, wherein the aprotic solvent is an amide, an ester of a carboxylic acid, an ester of a fatty acid, an ester of an acid, an ester of an alcohol, an ether, a ketone, a lactone or a sulfoxide, and wherein the aprotic solvent is not tribehenin.
Dependencies are inferred from the claim text.