Method of treating postprandial inflammation and preventing weight gain
AssigneeDasman Diabetes Institute
InventorsFATEMA AL-RASHED, RASHEED AHMAD
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Abstract
A method of treating postprandial inflammation, or inhibiting an inflammatory response in a subject, may include administering to a subject an edible composition comprising an ACSL1 inhibitor. The ACSL1 inhibitor may be administered before or during consumption of a food high in fat, particularly a food high in saturated fat. The ACSL1 inhibitor may prevent a pro-inflammatory response, weight gain, or the development or progression of a disease associated with the consumption of high fat foods, such as dyslipidemia, obesity, diabetes, arthritis, or hepatic steatosis.
Claims20
A method of inhibiting an inflammatory response in a subject, comprising administering an ACSL1 inhibitor or a pharmaceutically acceptable salt thereof to a subject in need thereof in an amount effective to inhibit an increase in inflammatory markers or monocyte polarization to pro-inflammatory macrophages resulting from the subject's consumption of a food that is high in at least one saturated fatty acid.
A method of preventing weight gain in a subject, comprising administering a daily dose of an effective amount of an ACSL1 inhibitor or a pharmaceutically acceptable salt thereof to a subject in need thereof.
A method of preventing the development or progression of a disease associated with consumption of high fat foods in a subject, comprising administering a daily dose of an effective amount of an ACSL1 inhibitor or a pharmaceutically acceptable salt thereof to a subject in need thereof.
Dependencies are inferred from the claim text.