Film-Based Dosage Form
AssigneeSoluble Technologies LLC
InventorPankaj Modi
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Abstract
A film-based dosage form is provided. The dosage form includes a film base comprising a film-forming agent, a plasticizer and a solvent; and a matrix incorporated within the film base which comprises a target molecule that exhibits low aqueous solubility which is encapsulated and solubilized in a micellar formulation comprising a detergent in an aqueous solvent. The dosage form is particularly useful for administration of cannabinoids.
Claims21
A film-based dosage form comprising:
- i) a film base comprising a film-forming agent, a plasticizer and a solvent;
- and
- ii) a matrix within the film base comprising a target molecule that exhibits low aqueous solubility, wherein said target molecule is encapsulated in a micellar formulation comprising a detergent in an aqueous solvent.
A film-based capsule dosage form comprising:
- i) a film base in the form of a capsule shell comprising a film-forming agent, a plasticizer and a solvent;
- and
- ii) a matrix contained within the capsule shell comprising a target molecule that exhibits low aqueous solubility in an amount of 1%-50% by weight of the matrix encapsulated in a micellar formulation comprising a detergent in an amount of 0.01% to 10% by weight of the matrix, a lipase in an amount of 0.01 to 10 wt % of the matrix, a plasticizing agent in an amount of 0.01% to about 20% by weight of the matrix, an emulsifying agent in an amount of 0.01% to about 20% by weight of the matrix and an aqueous solvent as the balance of the formulation, wherein the target molecule is solubilized in the matrix.
The film-based dosage form of claim 26, wherein the film-forming agent is gelatin, the plasticizer is glycerin, the detergent is sodium dodecyl sulfate and a polyoxyethylene detergent and the target molecule is a cannabinoid.
Dependencies are inferred from the claim text.