Vitamin d micro-emulsioins and uses thereof
OwnerRafael Ezra, Yoni Manorinventors
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Abstract
Pharmaceutical compositions designed to deliver Vitamin D efficiently to the eyes and methods for using same are described herein. More particularly, ophthalmic pharmaceutical compositions for use in protecting eyes from the harmful effects of light exposure, in maintaining a healthy ocular state, and in treating disorders of the eye are described herein. The composition may also be used as a medical device which, once on the surface of the eye, creates a layer that filters electro-magnetic radiation in different wave lengths. The composition may also be used as a medical device which eases the symptoms and signs of eye-surface conditions.
Claims35
A pharmaceutical composition comprising:
- a phospholipid nano-emulsion comprising:
- phospholipids,
- wherein the phospholipids range from 0.1-5% w/v;
- emulsified particles;
- wherein the emulsified particles have a particle size ranging from 100-300 nanometers in diameter;
- and
- Vitamin D,
- wherein the Vitamin D ranges from 0.02-2% w/v of the pharmaceutical composition;
- wherein the phospholipids and the vitamin D are in a ratio of at least 3:1;
- and
- and
- wherein a therapeutically effective amount of the pharmaceutical composition is sufficient to absorb light in a wavelength range of 220-520 nm.
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A pharmaceutical composition comprising:
- a phospholipid nano-emulsion, comprising:
- phospholipids,
- wherein the phospholipids range from 0.1-5% w/v;
- emulsified particles,
- wherein the emulsified particles have a particle size ranging from 100-300 nanometers in diameter;
- and
- Vitamin D,
- wherein the Vitamin D ranges from 0.02-2% wt/vol or 0.07-1.4% wt/vol of the phospholipid nano-emulsion;
- wherein the phospholipids and the Vitamin D are in a ratio of at least 3:1 and
- wherein a therapeutically effective amount of the pharmaceutical composition is sufficient to deliver the Vitamin D to corneal tissue of an eye for a prolonged duration,
- wherein the prolonged duration is at least 1-10 minutes.
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Dependencies are inferred from the claim text.