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AssigneeBoard of Regents, The University of Texas System
InventorsHugh D.C. SMYTH, Hairui ZHANG, Zhengrong CUI, Jieliang WANG, Haiyue XU, Yajie ZHANG, Debadyuti GHOSH, Jasmim LEAL, Melissa SOTO, Robert O. WILLIAMS, III, Chaeho MOON, Sawittree SAHAKIJPIJARN
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Dry powder compositions comprising biologically active polynucleotide molecules and methods for the manufacture of such dry powders are provided. In some aspects, dry powders of the embodiment comprise expressible or regulatory (e.g., siRNA) polynucleotide molecules complexed with nanoparticles. Dry powders comprising viable virus and bacteria are also provided.
A dry powder comprising a biologically active polynucleotides and at least a first excipient, said dry powder having been produced by an ultra-rapid freezing process (URF), wherein the biologically active polynucleotides retain substantial biological activity and/or have been stabilized by the URF process.
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A method of producing powder pharmaceutical composition comprising:
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Dependencies are inferred from the claim text.