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US 2022/0023199 A1Published application
Transmucosal and transdermal delivery systems
AssigneeMedlab Clinical U.S., Inc.
InventorsDavid A. Rutolo, JR., Sean Michael Hall, Luis Vitetta, Yusi Zhou, Samantha Maree Coulson
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Abstract
Provided herein are transmucosal and transdermal delivery systems comprising: at least one non-ionic surfactant; at least one polyol; and at least one active agent; and optionally further comprising at least one oil. In particular embodiments, the delivery system has an average particle size of from about 5 nm to about 200 nm.
Claims19
A transmucosal and/or transdermal delivery system, comprising a micelle composition which comprises:
- one or more surfactants, wherein the one or more surfactants consist of at least one non-ionic surfactant having a Hydrophile-Lipophile Balance (HLB) value of from about 12 to about 16;
- at least one polyol;
- at least one active agent;
- at least one oil;
- and
- water, at a ratio of said water to the at least one active agent, the at least one non-ionic surfactant and the at least one polyol that is from 4:1 to 1:1 by weight,
- and wherein the micelle composition has:
- (i) a viscosity of from about 5 cP to about 35 cP when measured at 25° C. on a Brookfield viscometer with spindle #1 at 20 rpm;
- and (ii) an average particle size of from about 5 nm to about 200 nm.
6 more elements
Dependencies are inferred from the claim text.