Dermal filler compositions
AssigneeAllergan, Inc.
InventorsGabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
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Abstract
The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
Claims20
A dermal filler composition comprising hyaluronic acid (HA) crosslinked with lysine, the composition comprising:
- a HA component crosslinked in conjunction with a diamine crosslinker and a carbodiimide coupling agent, wherein the diamine crosslinker is lysine or lysine methyl ester, and wherein the crosslinked hyaluronic acid (HA) has a particle size from 10 μm to 1000 μm in diameter.
A dermal filler composition comprising hyaluronic acid (HA) crosslinked with lysine, the composition comprising:
- a HA component crosslinked in conjunction with a diamine crosslinker and a carbodiimide coupling agent, wherein the diamine crosslinker is lysine or lysine methyl ester, and wherein the crosslinked hyaluronic acid is present at a concentration of 10 to 40 mg/ml.
A method of making an injectable dermal filler composition comprising hyaluronic acid (HA) crosslinked with lysine, the method comprising:
- crosslinking HA with a diamine crosslinker in the presence of a carbodiimide coupling agent, wherein the diamine crosslinker is lysine or lysine methyl ester;
- and
- sizing the crosslinked hyaluronic acid (HA) to a particle size from 10 μm to 1000 μm in diameter.
A method of making an injectable dermal filler composition comprising hyaluronic add (HA) crosslinked with lysine, the method comprising:
- crosslinking HA with a diamine crosslinker in the presence of a carbodiimide coupling agent, wherein the diamine crosslinker is lysine or lysine methyl ester, and wherein the crosslinked hyaluronic acid is present at a concentration of 10 to 40 mg/ml.
Dependencies are inferred from the claim text.