Method and device for the enhancement of topical treatments for oral mucositis and other oral conditions

A method of enhance absorption of a therapeutic agent sublingually in a person, the method comprising:

• administering a therapeutically effective amount of the therapeutic agent sublingually in a person;
• inserting, in a mouth of the person, a device comprising an oral retention portion that is suitably shaped to be retained in an oral cavity for a predetermined treatment period to enhance the absorption of the therapeutic agent sublingually;
• and
• wherein the device is further defined to have a fitting portion having an arcuate shape corresponding to a dental arche of the person, the fitting portion has an interior surface facing the person's teeth and has an exterior surface facing the person's check and gums, and the fitting portion further configured to have a front middle section with ends on either side of the front middle section such that the ends of the fitting portion are positioned towards the person's back teeth, an upper bite flange and a lower bite flange extending from the interior surface of the fitting portion forming a bite wedge along each end of the fitting portion, a covering portion extending upwardly and downwardly from the exterior surface of the fitting portion, the covering portion further extending from the middle section toward each end of the fitting portion, such that the covering portion defines an upper wing portion positioned at each end of the fitting portion, and a lower wing portion positioned at each end of the fitting portion, and
• wherein each lower wing portion further includes a v-shaped notch being positioned adjacent each bite wedge towards the middle section such that wherein the lower surface edge along the middle section of the fitting portion extends arcuately towards each lower wing portion the v-shaped notch defines a gap between the lower surface edge and a lower tab extending from the lower bite flange.