Esophagus catheter for irreversible electroporation

A method using an electroporation ablation device, the method comprising:

• disposing a first catheter of the electroporation ablation device anatomically approximate to a target ablation location in an extracardiac chamber, the first catheter comprising one or more first electrodes;
• disposing a second catheter of the electroporation ablation device approximate to the target ablation location in an intracardiac chamber, the second catheter comprising one or more second electrodes;
• and
• generating an electric field between the one or more first electrodes and the one or more second electrodes with electric field strength sufficient to ablate the target tissue via irreversible electroporation.

An electroporation ablation system, comprising:

• an electroporation ablation device comprising:
• a first catheter comprising one or more first electrodes and having a first surface area, and
• a second catheter comprising one or more second electrodes and having a second surface area,
• a pulse generator configured to generate and deliver ablative energy to the electroporation ablation device, and
• a controller coupled to the pulse generator and the electroporation ablation device,
• wherein the first surface area is larger than the second surface area,
• wherein when the electroporation ablation device is in operation for ablating a target tissue,
• the first catheter is configured to be disposed in an esophagus and anatomically proximate to the target tissue, and
• the second catheter is configured to be disposed at an intracardiac location proximate to the target tissue.