Transcutaneous organ function measurement

A device for determining an organ function in a subject in need thereof, said device comprising:

• a first sensor for transcutaneously measuring a first concentration-time curve in a first body fluid at a first position on the subject;
• a second sensor for transcutaneously measuring a second concentration-time curve in a second body fluid at a second position on the subject;
• and
• a data processing unit for fitting the values obtained by the sensors into a kinetic model;
• wherein the first body fluid and the second body fluid of the subject may be the same or different, and said first sensor and said second sensor are operatively linked in that the data processing unit of the device is configured to bring together the results of the measurements performed by said sensors and fits the data into the kinetic model.

A method for determining an organ function in a subject, the method comprising:

• administering a fluorescent indicator compound to the subject;
• measuring transcutaneously a first concentration-time curve at a first position on the subject, wherein said first concentration time curve comprises (i) at least one data point collected prior to administering the fluorescent indicator compound to the subject as a first background time point, and (ii) at least five data points collected after administering the fluorescent indicator compound to the subject;
• simultaneously measuring transcutaneously a second concentration-time curve at a second position on the subject, wherein said second concentration time curve comprises (i) at least one data point collected prior to administering the fluorescent indicator compound to the subject as a second background time point, and (ii) at least five data points collected after administering the fluorescent indicator compound to the subject;
• measuring a concentration of the indicator compound in a body fluid within the time frame of the transcutaneous measurement;
• and
• fitting the first concentration-time curve, the second concentration-time curve and the concentration of the indicator compound in the body fluid into a kinetic model representing two or three or four diffusion compartments, wherein the diffusion compartments are selected from the group consisting of plasma, interstitial fluid, local interstitium at the position of the measuring, and distribution.