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AssigneeIcoat Medical AB
InventorsBo NILSSON, Kristina NILSSON EKDAHL, Marianne JENSEN WAERN, Yuji TERAMURA, Alireza BIGLARNIA
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An organ graft is ex vivo treated by ex vivo infusing a solution comprising PEG-phospholipid molecules into a vascular system of the organ graft. The solution comprising PEG-phospholipid molecules is ex vivo incubated in the vascular system to enable coating of at least a portion of the endothelial lining of the vascular system with the PEG-phospholipid molecules while keeping the organ or the part of the organ submerged in an organ preservation solution comprising PEG-phospholipid molecules. Such an ex vivo treatment of organ grafts with PEG-phospholipid protected the organ grafts against thromboinflammation and reduced blood pressure drops that otherwise occurred when reperfusing the organ graft in the recipient.
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An ex vivo method of treating an organ or a part of the organ, the method comprising:
A method for treating, inhibiting or preventing hypotension associated with reperfusion developing after reperfusion of an organ graft, the method comprises:
Dependencies are inferred from the claim text.