Methods of obtaining 3d retinal blood vessel geometry from optical coherent tomography images and methods of analyzing same

A method of distinguishing between a plurality of retinal layers from vessel morphology information of retinal blood vessels in a 3D optical coherence tomography (OCT) image, comprising a plurality of OCT images, of at least a portion of a retina, the method comprising:

• using at least one computer programmed to perform:
• obtaining a geometrical representation of a vascular tree or vessel network of retinal blood vessels from the 3D OCT image;
• evaluating at least one first morphological feature of at least one retinal blood vessel at each of a plurality of voxel locations in the geometrical representation;
• and
• determining that at least one first voxel location of the plurality of voxel locations belongs to a first layer of the plurality of retinal layers and that at least one second location of the plurality of voxel locations belongs to a second layer of the plurality of retinal layers based on evaluating the at least one first morphological feature.