Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides
AssigneeAlpha Anomeric SAS
InventorWolfgang RENNER
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Abstract
The invention provides for an oligonucleotide lipid group conjugate, wherein the oligonucleotide comprises at least two alpha anomeric bicyclo-DNA residues connected by a phosphodiester bond, and wherein the lipid group is attached to the oligonucleotide via a linker. The invention also provides for methods of modulating gene expression using an oligonucleotide lipid group conjugate.
Claims31
An oligonucleotide-lipid group conjugate wherein the oligonucleotide comprises at least two alpha anomeric bicyclo-DNA (abc-DNA) residues connected by a phosphodiester bond and wherein said lipid group is covalently attached to the oligonucleotide.
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Dependencies are inferred from the claim text.