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US 2022/0017875 A1Published application
Methods of predicting ancestral virus sequences and uses thereof
AssigneesMassachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
InventorsLuk H. Vandenberghe, Eric Zinn
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Abstract
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
Claims25
1-9. (canceled)
A method comprising:
- administering to a subject in need thereof a plurality of recombinant adeno-associated virus (rAAV) particles, wherein each rAAV particle comprises an AAV capsid polypeptide and a transgene, wherein the AAV capsid polypeptide comprises an amino acid sequence chosen from:
- SEQ ID NOs:
- 1, 3, 5, 7, 9, 11, 13, 15, and 17, and the transgene is within the rAAV particle.
A method comprising:
- administering to a subject in need thereof a plurality of recombinant adeno-associated virus (rAAV) particles, wherein each rAAV particle comprises an AAV capsid polypeptide and a transgene, wherein the AAV capsid polypeptide comprises an amino acid sequence chosen from:
- SEQ ID NOs:
- 19, 20, 21, 22, 23, 24, 25, and 26, and the transgene is within the rAAV particle.
Dependencies are inferred from the claim text.