Mageb2 binding constructs

An isolated antibody construct comprising a first domain that binds to a pMAGE-HLA on the surface of a target cell, and a second domain that binds to human CD3 on the surface of a T cell, wherein the first domain comprises:

• a) a VH region comprising CDR-H1 as depicted in SEQ ID NO:
• 439, CDR-H2 as depicted in SEQ ID NO:
• 440, and CDR-H3 as depicted in SEQ ID NO:
• 441, and a VL region comprising CDR-L1 as depicted in SEQ ID NO:
• 223, CDR-L2 as depicted in SEQ ID NO:
• 224 and CDR-L3 as depicted in SEQ ID NO:
• 225;
• or
• b) a VH region comprising CDR-H1 as depicted in SEQ ID NO:
• 361, CDR-H2 as depicted in SEQ ID NO:
• 362, and CDR-H3 as depicted in SEQ ID NO:
• 363, and a VL region comprising CDR-L1 as depicted in SEQ ID NO:
• 145, CDR-L2 as depicted in SEQ ID NO:
• 146 and CDR-L3 as depicted in SEQ ID NO:
• 147;
• or
• c) a VH region comprising CDR-H1 as depicted in SEQ ID NO:
• 523, CDR-H2 as depicted in SEQ ID NO:
• 524, and CDR-H3 as depicted in SEQ ID NO:
• 525, and a VL region comprising CDR-L1 as depicted in SEQ ID NO:
• 307, CDR-L2 as depicted in SEQ ID NO:
• 308 and CDR-L3 as depicted in SEQ ID NO:
• 309;
• or
• d) a VH region comprising CDR-H1 as depicted in SEQ ID NO:
• 331, CDR-H2 as depicted in SEQ ID NO:
• 332, and CDR-H3 as depicted in SEQ ID NO:
• 333, and a VL region comprising CDR-L1 as depicted in SEQ ID NO:
• 115, CDR-L2 as depicted in SEQ ID NO:
• 116 and CDR-L3 as depicted in SEQ ID NO:
• 117;
• or
• e) a VH region comprising CDR-H1 as depicted in SEQ ID NO:
• 337, CDR-H2 as depicted in SEQ ID NO:
• 338, and CDR-H3 as depicted in SEQ ID NO:
• 339, and a VL region comprising CDR-L1 as depicted in SEQ ID NO:
• 121, CDR-L2 as depicted in SEQ ID NO:
• 122 and CDR-L3 as depicted in SEQ ID NO:
• 123;
• or
• f) a VH region as depicted in SEQ ID NO:
• 629, and a VL region as depicted in SEQ ID NO:
• 628;
• or
• g) a VH region as depicted in SEQ ID NO:
• 577, and a VL region as depicted in SEQ ID NO:
• 576;
• or
• h) a VH region as depicted in SEQ ID NO:
• 684, and a VL region as depicted in SEQ ID NO:
• 685;
• or
• i) a VH region as depicted in SEQ ID NO:
• 557, and a VL region as depicted in SEQ ID NO:
• 556;
• or
• j) a VH region as depicted in SEQ ID NO:
• 561, and a VL region as depicted in SEQ ID NO:
• 560.