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AssigneeKyowa Kirin Co., Ltd.
InventorsKeisuke MITAMURA, Ryosuke NAKANO, Masayuki KAI, Nobuaki TAKAHASHI
Estimating the term…
The present invention relates to a bispecific antibody in which an N-terminal side polypeptide is bound to an IgG portion that binds to TfR, a bispecific antibody fragment thereof, a DNA encoding the bispecific antibody or the bispecific antibody fragment thereof, a vector containing the DNA, a hybridoma and a transformant that produce the bispecific antibody or the bispecific antibody fragment thereof, a method for producing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic agents containing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic methods using the bispecific antibody or the bispecific antibody fragment thereof, and a reagent for detection or measurement containing the bispecific antibody or the bispecific antibody fragment thereof.
A bispecific antibody or a bispecific antibody fragment thereof, which binds to a transferrin receptor (TfR) and a cell surface antigen, including an IgG portion that binds to TfR and an N-terminal side polypeptide that binds to the cell surface antigen, wherein the N-terminal side polypeptide binds directly or through a linker to the N terminus of a heavy chain of the IgG portion.
24-25. (canceled)
28-32. (canceled)
Dependencies are inferred from the claim text.