Anti-ox40 monoclonal antibody and application thereof

An anti-OX40 antibody or antigen-binding fragment thereof, comprising at least one of:

• (1) a heavy chain variable region comprising amino acid sequences of GFTFSDYY SEQ ID NO:
• 18, ISDGGSNT SEQ ID NO:
• 19 and ARRGTGTGFGY SEQ ID NO:
• 20, and a light chain variable region comprising amino acid sequences of ENIYST SEQ ID NO:
• 21, AAT and QHFWGIPWT SEQ ID NO:
• 22;
• (2) a heavy chain variable region comprising amino acid sequences of GYTFTNYD SEQ ID NO:
• 23, IYPEDGST SEQ ID NO:
• 24 and ARDTRGYFDY SEQ ID NO:
• 25, and a light chain variable region comprising amino acid sequences of SSVNY SEQ ID NO:
• 26, YTS and QQFTSSPWT SEQ ID NO:
• 27;
• (3) a heavy chain variable region comprising amino acid sequences of GDSITSGY SEQ ID NO:
• 28, ISFSGNT SEQ ID NO:
• 29 and ARYPYSYSNWDYAMDY SEQ ID NO:
• 30, and a light chain variable region comprising amino acid sequences of QFLLYSSSQKNY SEQ ID NO:
• 31, WAS and HQYYSYPLT SEQ ID NO:
• 32;
• (4) a heavy chain variable region comprising amino acid sequences of GDSITIGF SEQ ID NO:
• 33, INYSGSS SEQ ID NO:
• 34 and ARSGTDLDY SEQ ID NO:
• 35, and a light chain variable region comprising amino acid sequences of QSLLDSDGKTY SEQ ID NO:
• 36, LVS and WQGTHFPRT SEQ ID NO:
• 37;
• and
• (5) an amino acid sequence of any of (1) to (4) with one or more conservative amino acid substitutions.